Aldactone (spironolactone, spironolactone) 100 mg, only 1 tablet should be taken in each 24 hour period.
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|Pronunciation||/ ˌ s p aɪ r ə n oʊ ˈ l æ k t oʊ n / SPY -rə-noh- LAK -tohn,  / ˌ s p ɪər -/ SPEER - |
|Trade names||Aldactone, Spiractin, Verospiron, many others; combinations: Aldactazide (+HCTZ), Aldactide (+HFMZ), Aldactazine (+altizide), others|
|Pregnancy category||AU: B3 US: C (Risk not ruled out)|
|Routes of administration||By mouth,  topical |
|Drug class||Antimineralocorticoid; Steroidal antiandrogen|
|ATC code||C03DA01 ( WHO )|
|Legal status||UK: POM (Prescription only) US: ℞-only|
|Bioavailability||60–90%   |
|Protein binding||Spironolactone: 88% (to albumin and AGP)  Canrenone: 99.2% (to albumin) |
|Metabolism||Liver, others: • Deacetylation via CES • S -Oxygenation via FOM • S -Methylation via TMT • Dethioacetylation • Hydroxylation via CYP3A4 • Lactone hydrolysis via PON3)       |
|Metabolites||7α-TS, 7α-TMS, 6β-OH-7α-TMS, canrenone, others    (All three active) |
|Elimination half-life||Spironolactone: 1.4 hours  7α-TMS: 13.8 hours  6β-OH-7α-TMS: 15.0 hrs  Canrenone: 16.5 hours |
|Excretion||Urine, bile |
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Serious and occasionally fatal hypersensitivity reactions including anaphylactoid and severe cutaneous adverse reactions have been reported in patients on penicillin therapy. Antibiotic-associated colitis has been reported with nearly all antibacterial agents and may range in severity from mild to life threatening see section 4.
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|Active substance||spironolactone, spironolactone|
|Best price||$0.37 per dose|
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Therapy can be started parenterally according to the dosing recommendations of the intravenous formulation and continued with an oral preparation. Renal impairment In patients with renal impairment, the dose should be adjusted according to the degree of impairment see section 4.
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The products are sourced from various countries as well as those listed above. Skin reactions The occurrence at the treatment initiation of a feverish generalised erythema associated with pustula may be a symptom of acute generalised exanthemous pustulosis AGEP, see section 4.
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