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Alendronic acid
Clinical data
Trade namesFosamax
AHFS/Drugs.comMonograph
MedlinePlusa601011
License dataEU  EMA:  by INN
Pregnancy categoryC
Routes of administrationOral
ATC codeM05BA04 ( WHO )
Legal status
Legal statusUK: POM (Prescription only)
Pharmacokinetic data
Bioavailability0.6%
Metabolismexcreted unchanged
Elimination half-life126 months
Excretionrenal

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In the Consumer Reports survey, Costco had the best prices for a brick-and-mortar store, while the online mail-order pharmacy Healthwarehouse. Some offers may be printed right from a website, others require registration, completing a questionnaire, or obtaining a sample from the doctor's office.

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Alendronate has a high degree of oesophageal toxicity, owing to its very low pH in aqueous solution de Groen et al. Over time, such microdamage might accumulate and cause a fracture. Patients who were previously stable on doses of brand alendronate experienced an increase in AEs which were serious enough to result in discontinuation after introduction of automatic substitution to generic alendronate.

However, in this investigation the authors found no difference between users of brand and generic alendronate in the incidence of upper GI AEs.

This is all largely speculative, as no studies have produced empirical evidence that such mechanisms actually lead to fractures. Clinicians diagnose osteoporosis by measuring bone mineral density with a technique known as dual-energy x-ray absorptiometry DXA.

Another class of drugs, selective estrogen receptor modulators SERMSrelated website includes the brand-name drug Evista, act like estrogen in the body without increasing risk of uterine and possibly breast cancers as estrogen could.

Wait at least 5 minutes after the effervescence stops and then stir the solution for 10 seconds and drink it.

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However, due to stock shortages and other unknown variables we cannot provide any guarantee. There are currently no Patient Assistance Programs that we know about for this drug.

Click here for the full Consumer Reports story. Many consumers assume their pharmacy has the best price, or close to it.

Another type of drug, Forteo, which can actually rebuild bone instead of just stopping bone loss, is a synthetic version of the hormone parathyroid. In the past few years, reports have emerged linking bisphosphonates with osteonecrosis bone death of the jaw and atrial fibrillation. Brand alendronate has undergone years of carefully monitored randomized placebo-controlled clinical trials, utilizing tens of thousands of osteoporosis patients, to establish tolerability, safety and efficacy.

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Commercially-available orally disintegrating tablets designed to dissolve in the mouth without water prior to swallowing were purposefully included to act as disintegration comparators. Certain diseases, such as celiac disease, lupus, and rheumatoid arthritismay worsen bone buy generic baclofen and increase the risk of osteoporosis, according to the National Institute of Arthritis and Musculoskeletal and Skin Diseases.

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Ask your doctor if you have any questions. In addition, reductions in bone mineral density were observed in some patients who had stable bone mineral density while on brand alendronate prior to January We know that bisphosphonates stay in bone for years, so it's not clear that a "drug holiday" will lower your risk for possible long-term effects.

They reported that automatic generic substitution of generic alendronate was associated with reduced treatment persistence. The Mayo Clinic[ 1 ] offers an overview of medications used to treat osteoporosis.

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