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Fetal testing may be appropriate, based on the week of pregnancy. Following oral administration, plasma concentrations of losartan and its active metabolite decline polyexponentially, with a terminal half-life of about 2 hours and hours, respectively. Characteristics in patients In elderly hypertensive patients the plasma concentrations of losartan and its active metabolite do not differ essentially from those found in young hypertensive patients.

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Losartan administration results in a decrease in total peripheral resistance afterload and cardiac venous return preload. After discontinuation of losartan, PRA and angiotensin II values fell within three days to the baseline values.

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Following oral and intravenous administration of 14C-labelled losartan potassium, circulating plasma radioactivity primarily finasteride europe attributed to losartan and its active metabolite.

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