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Loratadine
Clinical data
Trade namesClaritin, Claratyne, others
AHFS/Drugs.comMonograph
MedlinePlusa697038
Pregnancy categoryAU: B1 US: B (No risk in non-human studies)
Routes of administrationby mouth
ATC codeR06AX13 ( WHO )
Legal status
Legal statusCA : OTC UK: General sales list (GSL, OTC) US: OTC
Pharmacokinetic data
Bioavailabilityalmost 100%
Protein binding97–99%
Metabolismliver (CYP2D6- and 3A4-mediated)
Elimination half-life8 hours, active metabolite desloratadine 27 hours
Excretion40% as conjugated metabolites into urine Similar amount into the feces

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