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Pronunciation | / ˈ aɪ b juː p r oʊ f ɛ n /, / aɪ b juː ˈ p r oʊ f ən /, EYE -bew- PROH -fən |
Trade names | Advil, Motrin, Nurofen, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682159 |
License data | EU EMA: by INN, US FDA: Ibuprofen |
Pregnancy category | AU: C US: C (Risk not ruled out) D (US) at ≥30 weeks of gestation, due to the potential for premature closure of the ductus arteriosus |
Routes of administration | by mouth, rectal, topical, and intravenous |
ATC code | C01EB16 ( WHO ) G02CC01 ( WHO ) M01AE01 ( WHO ) M02AA13 ( WHO ) R02AX02 ( WHO ) |
Legal status | |
Legal status | AU: OTC CA : OTC UK: General sales list (GSL, OTC) US: OTC (R x -only at higher doses) |
Pharmacokinetic data | |
Bioavailability | 80–100% (by mouth), [2] 87% (rectal) |
Protein binding | 98% [1] |
Metabolism | Liver (CYP2C9) [1] |
Onset of action | 30 min [3] |
Elimination half-life | 2–4 h [4] |
Excretion | Urine (95%) [1] [5] |
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