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In a study on diclofenac no such interaction could be detected. For migraine prevention, two common courses of treatment are to take a 10mg tablet three times a day; or an 80mg modified-release capsule just once a day. The dosage should be withdrawn gradually over a period of 7 to 14 days.

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A dose of 5 mg of rizatriptan is recommended for combination therapy. Concomittant use with alpha blockers increases the risk of hypotension, especially orthostatic hypotension, and tachycardia and palpitations with.

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Isolated reports of myasthenia gravis like syndrome or exacerbation of myasthenia gravis have been reported in patients administered propranolol.

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In case of combination, appropriate monitoring for treatment initiation, at least overnight monitoring is recommended.

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This might be the case, for example, in people under 18; people with asthma, COPD, or other breathing problems; diabetes; some heart conditions including heart failure, angina, peripheral vascular disease, or heart rhythm problems; and low blood pressure.

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Oxygen or artificial ventilation may be required in severe cases. Breast feeding is therefore not recommended following administration of these compounds. A few case reports suggest that patients treated with amiodarone can have severe sinus bradycardia when treated concomitantly with propranolol.

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