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|Pronunciation||/ s ɪ l ˈ d ɛ n ə f ɪ l / sil- DEN -ə-fil|
|Trade names||Viagra, Revatio, others|
|License data||EU EMA: by INN, US FDA: Sildenafil|
|Pregnancy category||AU: B1 US: B (No risk in non-human studies)|
|Routes of administration||By mouth (tablets), IV|
|ATC code||G04BE03 ( WHO )|
|Legal status||AU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only In general: ℞ (Prescription only)|
|Bioavailability||41% (mean) |
|Metabolism||Liver: CYP3A4 (major route), CYP2C9 (minor route)|
|Metabolites||N -desmethylsildenafil (~50% potency for PDE 5 )|
|Elimination half-life||3–4 hours|
|Excretion||Feces (~80%), urine (~13%) |
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The tipping point this time could be that an FDA advisory panel approved the drug on June 4 with a vote of 18 to 6 in favor of the drug. Please read the rules before joining the discussion.
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