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Paroxetine
Clinical data
Trade namesPaxil, Pexeva, Seroxat, others
AHFS/Drugs.comMonograph
MedlinePlusa698032
License dataUS   FDA: Paroxetine
Pregnancy categoryAU: D US: D (Evidence of risk)
Routes of administrationOral
ATC codeN06AB05 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only In general: ℞ (Prescription only)
Pharmacokinetic data
BioavailabilityExtensively absorbed from the GI tract, but extensive first-pass metabolism in the liver [1] [2] [3] [4]
Protein binding93–95% [1] [2] [3]
MetabolismExtensive, hepatic (mostly CYP2D6-mediated) [1] [2] [3]
Elimination half-life21 hours [1] [2] [3]
ExcretionRenal (64%; 2% unchanged and 62% as metabolites), Faecal (36%; <1% unchanged) [1] [2] [3]

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