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Letrozole
Clinical data
Trade namesFemara, others
AHFS/Drugs.comMonograph
MedlinePlusa698004
License dataUS   FDA: Letrozole
Pregnancy categoryUS: D (Evidence of risk)
Routes of administrationBy mouth (tablets)
Drug classAromatase inhibitor; Antiestrogen
ATC codeL02BG04 ( WHO )
Legal status
Legal statusCA : Schedule VII UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability99.9%
Protein binding60%, mainly to albumin
Metabolismpharmacologically-inactive carbinol metabolite (4,4΄-methanol-bisbenzonitrile) [1]
Elimination half-life2 days [1]
ExcretionKidneys [1]

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Active substance letrozole, letrozole
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