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Clomipramine
Clinical data
Trade namesAnafranil, Clomicalm, others
AHFS/Drugs.comMonograph
MedlinePlusa697002
License dataUS   FDA: Clomipramine
Pregnancy categoryAU: C US: C (Risk not ruled out)
Routes of administrationBy mouth, intravenous [1]
ATC codeN06AA04 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability~50% [3]
Protein binding96–98% [3]
MetabolismHepatic (CYP2D6) [3]
MetabolitesDesmethylclomipramine [3]
Elimination half-lifeCMI: 19–37 hours [3] DCMI: 54–77 hours [3]
ExcretionRenal (51–60%) [3] Feces (24–32%) [3]

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