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Provigil (modafinil, modafinil) 100 mg, the maximum recommended dosing frequency is once per day.

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Clinical data
Trade namesProvigil, Alertec, Modavigil, others
License dataUS   FDA: Modafinil
Pregnancy categoryAU: B3 US: C [3]
Dependence liabilityPsychological: Very low [1] Physical: Negligible [1]
Addiction liabilityVery low to low [2]
Routes of administrationBy mouth (tablets) [3]
ATC codeN06BA07 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) UK: POM (Prescription only) US: Schedule IV
Pharmacokinetic data
BioavailabilityNot determined due to the aqueous insolubility
Protein binding62%
MetabolismHepatic (primarily via amide hydrolysis; [4] CYP1A2, CYP2B6, CYP2C9, CYP2C19, CYP3A4, CYP3A5 involved [5]
Elimination half-life15 hours ( R -enantiomer), 4 hours ( S -enantiomer) [6]
ExcretionUrine (80%)

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6 mgkg orally once a day or 1. 3 mgkg orally twice a day. - Initial dose: 240 mg orally on the first day, given in 2 divided doses (120 mg every 12 hours).

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Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof.

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