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Clinical data | |
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Pronunciation | / ˌ m ɛ θ ə ˈ t r ɛ k ˌ s eɪ t, ˌ m iː -, - θ oʊ -/ ( listen ) [2] [3] [4] |
Trade names | Trexall, Rheumatrex, others [1] |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682019 |
License data | EU EMA: by INN, US FDA: Methotrexate |
Pregnancy category | AU: D US: X (Contraindicated) |
Routes of administration | By mouth, IV, IM, SC, intrathecal |
ATC code | L01BA01 ( WHO ) L04AX03 ( WHO ) |
Legal status | |
Legal status | AU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only In general: ℞ (Prescription only) |
Pharmacokinetic data | |
Bioavailability | 60% at lower doses, less at higher doses. [5] |
Protein binding | 35–50% (parent drug), [5] 91–93% (7-hydroxymethotrexate) [6] |
Metabolism | Hepatic and intracellular [5] |
Elimination half-life | 3–10 hours (lower doses), 8–15 hours (higher doses) [5] |
Excretion | Urine (80–100%), faeces (small amounts) [5] [6] |
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