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Quetiapine
Clinical data
Pronunciation/ k w ɪ ˈ t aɪ . ə p iː n / kwi- TY -ə-peen
Trade namesSeroquel, Temprolide, others
AHFS/Drugs.comMonograph
MedlinePlusa698019
License dataUS   FDA: Quetiapine
Pregnancy categoryAU: B3 US: C (Risk not ruled out)
Routes of administrationBy mouth
ATC codeN05AH04 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability100% [2]
Protein binding83% [3]
MetabolismLiver via CYP3A4-catalysed sulfoxidation to its active metabolite norquetiapine (N-desalkylquetiapine) [1]
Elimination half-life7 hours (parent compound); 9–12 hours (active metabolite, norquetiapine) [3] [4]
ExcretionKidney (73%), faeces (20%) [2] [3] [4] [5]

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Decompressive craniectomy in patients with uncontrol-lable intracranial hypertension. A specific Acetylcholines-terase—AChE or true cholinesterase and anonspecific Butyrylcholinesterase—BuChE orpseudocholinesterase type of enzyme occurs inthe body; important differences between these twotypes of the enzyme are given in Table 7.

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